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Kyathanahalli C*, Snedden M*, Singh L, Regalia C, Keenan-Devlin L, Borders AB, Hirsch E (*co-first authors). Maternal plasma and salivary anelloviruses in pregnancy and preterm birth. Front Med (2023). doi: 10.3389/fmed.2023.1191938

Suresh S, MacGregor C, Dude A, Hirsch E. Single second trimester cervical length is predictive of preterm delivery among patients with prophylactic cerclage. Am J Obstet Gynecol (2022). doi: 10.1016/j.ajog.2022.07.018

Suresh SC, Freedman A, Hirsch E, Ernst L. A comprehensive analysis of the association between placental pathology and recurrent preterm birth. Am J Obstet Gynecol (2022). doi: 10.1016/j.ajog.2022.06.030.

de Los Reyes S, Singh L, Adams M, Wang C, Hirsch E. Glucose Testing in an Index Pregnancy and Outcomes in a Subsequent Pregnancy: Implications for Screening and a Novel Risk Calculator. Am J Perinatol. 2022 Nov 25. doi: 10.1055/s-0042-01758484.

Snedden M, Singh L, Kyathanahalli C, Hirsch E. Toxic effects of trace phenol/guanidine isothiocyanate (P/GI) on cells cultured nearby in covered 96-well plates. BMC Biotechnol. 2022 Nov 25;22(1):35. doi: 10.1186/s12896-022-00766-2.

Kyathanahalli C, Snedden M, Hirsch E. Is Human Labor at Term an Inflammatory Condition?
Biol Reprod. 2022 Sep 29. doi: 10.1093/biolre/ioac182.

Kyathanahalli C, Snedden M, Hirsch E. Human Anelloviruses: Prevalence and Clinical Significance During Pregnancy​. Front. Virol​. 2021 Dec 7.  doi: 10.3389/fviro.2021.782886.

de Los Reyes S, Dude A, Adams M, Plunkett B, Hirsch E. Elevated Glucose Challenge Test in a Nondiabetic Index Pregnancy and Gestational Diabetes in a Subsequent Pregnancy. Am J Perinatol​. 2021 May 27.  doi: 10.1055/s-0041-1729878.

Mishra P, Hirsch E. Variable responsiveness to agonists for TLR2 and TLR7 in myometrial cells from different sources: correlation with receptor expression. Reprod. Sci. 27, 996–1001 (2020). doi: 10.1007/s43032-019-00064-x.

Shah AA, Wang D, Hirsch E. Nucleic acid-based screening of maternal serum to detect viruses in women with labor or PROM. Reproductive Sciences. 2020 Jan 10 Epub ahead of print. doi: 10.1007/s43032-019-00051-2.

Scholz RC, Smith BA, Adams MG, Shah M, Brudner C, Datta A, Hirsch E. A multi-faceted surgical site infection prevention bundle for cesarean delivery. Am J Perinatol (2019) Epub ahead of print. doi: 10.1055/s-0039-3400993.


Agrawal V, Jaiswal MK, Beaman KD, Hirsch E. Surfactant protein A suppresses preterm delivery induced by live Escherichia coli in mice. Biol Reprod. 2018 Sep 1; 99(3):546-555. doi: 10.1093/biolre/ioy074.

Dambaeva S, Schneiderman S, Jaiswal MK, Agrawal V, Katara G, Gilman-Sachs A, Hirsch E, Beaman KD. IL-22 Prevents Lipopolysaccharide-Induced Preterm Labor in Mice. Biol Reprod. 2018 Mar 1;98(3):299-308. doi: 10.1093/biolre/iox182.

Thaete LG, Qu X-W, Neerhof MG, Hirsch E, Jilling T. Fetal growth restriction induced by transient uterine ischemia-reperfusion: Differential responses in different mouse strains. Reprod Sci. (2017). doi: 10.1177/1933719117732160.

Turrentine M, Colicchia LC, Hirsch E, Cheng P-J, Tam T, Ramsey PS, Page-Ramsey SM. Efficiency of screening for the recurrence of antenatal Group B Streptococcus colonization in a subsequent pregnancy: A systematic review and meta-analysis with independent patient data. Am J Perinatol (2016) 33:510-7. doi: 10.1055/s-0035-1569988. PMID: 26683604

Filipovich, Y, Klein J, Zhou Y, Hirsch E. Maternal and fetal roles in bacterially-induced preterm labor in the mouse. Am J Obstet Gynecol (2016) 214:386.e1-9. doi: 10.1016/j.ajog.2015.10.014. PMID: 26478101

Agrawal V*, Jaiswal MK*, Pamarthy S, Katara G, Kulshrestha A, Gilman-Sachs A, Hirsch E, Beaman KD  (*co-first authors). Role of Notch signaling during lipopolysaccharide-induced preterm labor. J Leukoc Biol. (2016) 100:261-74 doi: 10.1189/jlb.3HI0515-200RR. PMID: 26373439. Featured as “Leading Edge Research” with a press release on the FASEB website.

Jaiswal MK*, Agrawal V*, Pamarthy S, Katara GK, Kulshrestha A, Gilman-Sachs A, Beaman KD and Hirsch E (*co-first authors). Notch signaling in inflammation-induced preterm labor. Sci Rep. 2015 Oct 16;5:15221. doi: 10.1038/srep15221. PMID: 26472156

Filipovich Y, Agrawal V, Crawford SE, Fitchev P, Qu X, Klein J; Hirsch E. Depletion of polymorphonuclear leukocytes has no effect on preterm delivery in a mouse model of E. coli-induced labor. Am J Obstet Gynecol. (2015) 213:697.e1-10. doi: 10.1016/j.ajog.2015.07.025. PMID: 26215328.

Agrawal V, Jaiswal MK, Mallers T, Gilman-Sachs A, Beaman KD, Hirsch E. Altered autophagic flux enhances inflammatory responses during inflammation-induced preterm labor. Sci Rep (2015) 5:9410. doi: 10.1038/srep09410

Lu J, Reese J, Zhou Y, Hirsch E. Progesterone-induced activation of membrane-bound progesterone receptors in murine macrophage cells. J Endocrinol (2015) 224:183-194. DOI: 10.1530/JOE-14-0470

Agrawal V, Jaiswal MK, Ilievski V, Beaman KD, Jilling T, Hirsch E. Platelet Activating Factor (PAF): A role in preterm delivery and an essential interaction with toll-like receptor (TLR) signaling in mice. Biol Reprod (2014) Nov;91(5):119. DOI: 10.1095/biolreprod.113.116012. Epub Sep 24.

Colicchia LC, Lauderdale DS, Du H, Adams M, Hirsch E. Recurrence of Group B Streptococcus Colonization in Successive Pregnancies. J Perinatol. 2015 Mar;35(3):173-6. doi: 10.1038/jp.2014.185. Epub 2014 Oct 1

Hirsch E, Elue R, Wagner A, Nelson K, Silver RK, Zhou Y, Adams MG. Severe perineal laceration during operative vaginal delivery: the impact of occiput posterior position. J Perinatol (2014) 34:898-900. doi: 10.1038/jp.2014.103. Epub 2014 May 29.

Jaiswal MK, Agrawal V, Mallers T, Gilman-Sachs A, Hirsch E and Beaman KD. Regulation of Apoptosis and Innate Immune Stimuli in Inflammation Induced Preterm Labor. J Immunol (2013) 191:5702-13. PMID:24163412.

Agrawal V, Smart K, Jilling T, Hirsch E. Surfactant Protein (SP)-A Suppresses Preterm Delivery and Inflammation via TLR2. PLoS ONE (2013) 8 (5):e63390. DOI: 10.1371/journal.pone.0063990. PMID:23700442.

Thaete LG, Qu X-W, Jilling T, Crawford SE, Fitchev P, Hirsch E, Khan S and Neerhof MG. Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice. Reproduction (2013) 145: 517–526. DOI: 10.1530/REP-12-0433

Abramov Y, Hirsch E, Ilievski V, Goldberg RP, Botros SM, Sand PK.  Transforming Growth Factor Beta Gene Expression During Vaginal vs. Cutaneous Surgical Wound Healing in the Rabbit. Int Urogynecol J (2013) 24 (4):671-675. PMID: 22872035.

Abramov Y, Hirsch E, Ilievski V, Goldberg RP, Sand PK. Transforming Growth Factor Beta-1 Gene Expression During Vaginal Wound Healing in a Rabbit Menopause Model. BJOG, (2013) 120:251–6. DOI: 10.1111/j.1471-0528.2012.03447.x. PMID: 22827859.

Qu X-W, Jilling T, Neerhof MG, Luo K, Hirsch E, Thaete LG.  Unilateral uterine ischemia/reperfusion-induced bilateral fetal loss and fetal growth restriction in a murine model require intact complement component 5.  J Reprod Immunol 95 (2012) 27– 35. doi: 10.1016/j.jri.2012.04.005.

Abramov Y, Hirsch E, Ilievski V, Goldberg RP, Botros S, Sand PK. Expression of platelet-derived growth factor B mRNA during vaginal vs. dermal incisional wound healing in the rabbit. Eur J Obstet Gynecol Reprod Biol (2012) 162:216-20. DOI 10.1016/j.ejogrb.2012.03.012. PMID: 22464204.

Agrawal, V and Hirsch E. Intrauterine infection and preterm labor. Semin Fetal Neonatal Med (2012) 17: 12-19, DOI 10.1016/j.siny.2011.09.001.

Liu X, Wang G, Hong X, Tsai HJ, Liu R, Zhang S, Wang H, Pearson C, Ortiz K, Wang D, Hirsch E, Zuckerman B, Wang X.. Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black population. Hum Genet (2012) 2012131:341-51. DOI 10.1007/s00439-011-1079-5.

Tsai H-J, Hong X, Chen J, Liu X, Pearson C, Ortiz K, Hirsch E, Heffner L, Weeks DE, Zuckerman B, Wang X. The role of African ancestry and gene-environment interactions in predicting preterm birth. Obstet Gynecol (2011) 118(5):1081-1089.

Ilievski V and Hirsch E. Synergy between viral and bacterial toll-like receptors leads to amplification of inflammatory responses and preterm labor in the mouse. Biol Reprod (2010) 83:767-773,  doi:10.1095/biolreprod.110.085464.

Adams MG, Hirsch E, MacGregor SN, Kirschner CV and Silver RK. How Should We Respond to the Trend of Increasing Cesarean Delivery? Contemp OB Gyn. (2010) 55(6):30-38.

Hirsch E, Lim C, Dobrez D, Adams MG, Noble W. Meteorological factors and timing of the initiating event of human parturition. Int J Biometeorol. 2011 Mar;55(2):265-72. doi: 10.1007/s00484-010-0332-2. Epub 2010 Jun 6.

Equils O, Moffatt-Blue C, Ishikawa TO, Simmons CF, Ilievski V, Hirsch E. Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect Dis Obstet Gynecol. 2009;2009:749432. doi: 10.1155/2009/749432. Epub 2009 Dec 28.

Filipovich Y, Lu SJ, Akira S, Hirsch E. The adaptor protein MyD88 is essential for E coli-induced preterm delivery in mice. Am J Obstet Gynecol. 2009 Jan;200(1):93.e1-8. doi: 10.1016/j.ajog.2008.08.038.

Hirsch E, Filipovich Y, Romero R. Failure of E. coli bacteria to induce preterm delivery in the rat. J Negat Results Biomed. 2009 Jan 4;8:1. doi: 10.1186/1477-5751-8-1.

Hirsch E, Haney EI, Gordon TE, Silver RK. Reducing high-order perineal laceration during operative vaginal delivery. Am J Obstet Gynecol. 2008 Jun;198(6):668.e1-5. doi: 10.1016/j.ajog.2008.02.002. Epub 2008 Apr 8.

Ilievski V, Lu SJ, Hirsch E. Activation of toll-like receptors 2 or 3 and preterm delivery in the mouse. Reprod Sci. 2007 May;14(4):315-20.

Hirsch E, Filipovich Y, Mahendroo M. Signaling via the type I IL-1 and TNF receptors is necessary for bacterially induced preterm labor in a murine model. Am J Obstet Gynecol. 2006 May;194(5):1334-40. Epub 2006 Apr 21.

Yoshimura K, Hirsch E. Effect of stimulation and antagonism of interleukin-1 signaling on preterm delivery in mice. J Soc Gynecol Investig. 2005 Oct;12(7):533-8.

Hirsch E, Goldstein M, Filipovich Y, Wang H. Placental expression of enzymes regulating prostaglandin synthesis and degradation. Am J Obstet Gynecol. 2005 Jun;192(6):1836-42; discussion 1842-3.

Craft JM, Watterson DM, Hirsch E, Van Eldik LJ. Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid. J Neuroinflammation. 2005 Jun 20;2:15.

Hirsch E, Wang H. The molecular pathophysiology of bacterially induced preterm labor: insights from the murine model. J Soc Gynecol Investig. 2005 Apr;12(3):145-55. Review.

Yoshimura K, Hirsch E, Kitano R, Kashimura M. Cervical varix accompanied by placenta previa in twin pregnancy. J Obstet Gynaecol Res. 2004 Aug;30(4):323-5.

Yoshimura K, Hirsch E. Interleukin-6 is neither necessary nor sufficient for preterm labor in a murine infection model. J Soc Gynecol Investig. 2003 Oct;10(7):423-7.

Wang H, Hirsch E. Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. Biol Reprod. 2003 Dec;69(6):1957-63. Epub 2003 Aug 6.

Hirsch E, Muhle R. Intrauterine bacterial inoculation induces labor in the mouse by mechanisms other than progesterone withdrawal. Biol Reprod. 2002 Oct;67(4):1337-41.

Devlin CM, Kuriakose G, Hirsch E, Tabas I. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6280-5.

Hirsch E, Muhle RA, Mussalli GM, Blanchard R. Bacterially induced preterm labor in the mouse does not require maternal interleukin-1 signaling. Am J Obstet Gynecol. 2002 Mar;186(3):523-30.

Muhle RA, Pavlidis P, Grundy WN, Hirsch E. A high throughput study of gene expression in preterm labor with a subtractive microarray approach. Am J Obstet Gynecol (2001) 185:716-724.

Wong M-L, Xie B, Beatini N, Phu P, Marathe S, Johns A, Hirsch E, Williams KJ, Licinio J, Tabas I. Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo:  A possible new link between inflammatory cytokines and atherogenesis. Proc Natl Acad Sci USA (2000) 97(15):8681-8686.

Leslie KK, Lee SL, Woodcock SM, Davies JK, McDuffie RS, Hirsch E, Sherman MP, Eskens JL, Gibbs RS. Acute intrauterine infection results in an imbalance between pro- and anti-inflammatory cytokines in the pregnant rabbit. Am J Reprod Immunol (2000) 43(5):305-311.

Josephs MD, Solorzano CC, Ksontini R, Taylor M, Topping D, Abouhamze A, Mackay SLD, Hirsch E, Hirsh D, Labow M, Moldawer LL. Modulation of the acute phase response by altered expression of the IL-1 type 1 receptor or IL-1ra. Am J Physiol Regul Integr Comp Physiol (2000) 278:R824-R830.

Mussalli GM, Brunnert SR, Hirsch E. Preterm delivery in mice with renal abscess. Obstet Gynecol (2000) 95:453-6.

Mussalli GM, Blanchard RK, Brunnert SR, Hirsch E. Inflammatory cytokines in a murine model of infection-induced preterm labor: Cause or effect? J Soc Gynecol Invest (1999) 6:188-195.

Hirsch E, Otto T, Blanchard R, Rosenberg JO. Mouse laparoscopy. J Am Assoc Gynecol Laparosc (1999) 6: 173-177.

Irikura VM, Hirsch E, Hirsh D.  Effects of interleukin 1 receptor antagonist overexpression on infection by Listeria monocytogenes. Infect Immun (1999) 67: 1901-1909.

Mussalli GM, Brunnert SR, Hirsch E.  A murine model of renal abscess formation. Clin Diagn Lab Immunol (1999) 6:273-275.

Hirsch E, Mehta SP, Blanchard RK. Differential fetal and maternal contributions to the cytokine milieu in a murine model of infection-induced preterm birth. Am J Obstet Gynecol (1999) 180(2 Pt 1): 429-434.

Ma Y, Thornton S, Boivin GP, Hirsh D, Hirsch R, Hirsch E. Altered susceptibility to collagen induced arthritis in transgenic mice with aberrant expression of IL-1 receptor antagonist. Arthritis Rheum (1998) 41: 1798-1805.

Hirsch E. Born too soon: Cervical ultrasonography to predict preterm delivery is unproven. The Female Patient (1998) 23: 12-21.

Hirsch E. Anterior uterine incarceration. Int J Gynaecol Obstet (1997) 72:195-197.

Hirsch E, Irikura VM, Paul SM, Hirsh D.  Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. Proc Natl Acad Sci USA (1996) 93:11008-13.

Hirsch E, Saotome I, Hirsh D.  A model of intrauterine infection and preterm delivery in mice.  Am J Obstet Gynecol (1995) 172:1598-603.

Hirsch E, Cohen L, Hecht B.  Heterotopic pregnancy with discordant appearance of fetal cardiac activity.  Obstet Gynecol (1992) 79:824-5.


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